Why the study?
Serum antithrombin 3 activity decreases in type 2 diabetes, which confers increased thrombotic risk alongside impaired insulin sensitivity, but the relationship between insulin sensitivity indices and antithrombin 3 activity was unclear.
Population
1612 patients with type 2 diabetes
Comparison
Insulin sensitivity indices across serum AT3 activity levels
Design
Cross-sectional study
Authors
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May link insulin resistance to thrombotic risk via lower AT3 in T2D; hypothesis-generating and requires prospective validation.
Reduced basal and systemic insulin sensitivity are independently associated with decreased serum antithrombin 3 activity in patients with type 2 diabetes, potentially contributing to their increased thrombotic risk.
Wang et al. (2021) studied this question.
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