Key result
Children with insulin-dependent diabetes mellitus had significantly elevated mean plasma thrombin-antithrombin III complex levels compared to healthy controls (2.3 vs. 1.7 ng/mL, P<0.05).
Population
32 children with insulin-dependent diabetes mellitus, mean age 12.4 ± 3.7 years, mean duration of diabetes…
Design
Case-control
Authors
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May indicate early hypercoagulability in pediatric IDDM; hypothesis-generating and should not yet change practice.
Case-Control (n=64)
Yes
Absolute Event Rate: 2.3% vs 1.7%
p-value: p=<0.05
Insulin-dependent diabetic children exhibit a hypercoagulable state early in the disease course, as evidenced by elevated TAT and TX B2 levels, which are absent in those with good glycemic control.
Nukada et al. (1995) conducted a case-control in Insulin-dependent diabetes mellitus (n=64). Insulin-dependent diabetes mellitus vs. Healthy normal controls was evaluated on Mean plasma thrombin-antithrombin III complex (TAT) level (p=<0.05). Children with insulin-dependent diabetes mellitus had significantly elevated mean plasma thrombin-antithrombin III complex levels compared to healthy controls (2.3 vs. 1.7 ng/mL, P<0.05).
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