April 21, 2009Haemostasis
Heparin Preserves Antithrombin III Biological Activity from Hyperglycemia-Induced Alterations in Insulin-Dependent Diabetics
Why the study?
Does heparin administration restore antithrombin III biological activity in insulin-dependent diabetics?
Population
Insulin-dependent diabetic subjects
Authors
Discussion
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Member takes
Implication
In vitro heparin-ATIII effects in hyperglycemia models leave open any clinical role in insulin-dependent diabetes.
Structured PICO
Does heparin administration restore antithrombin III biological activity in insulin-dependent diabetics?
P
Population
Insulin-dependent diabetic subjects
I
Intervention
Subcutaneous and endovenous heparin administration
O
Outcome
Antithrombin III (ATIII) biological activitysurrogate
Heparin administration restores antithrombin III biological activity in insulin-dependent diabetics, suggesting a competitive mechanism between glucose and heparin for the same catalytic residue.
Cite This Study
Ceriello et al. (2009) studied this question.