Why the study?
Does intravenous heparin therapy affect plasma antithrombin levels in patients with deep venous thrombosis?
Does intravenous heparin therapy affect plasma antithrombin levels in patients with deep venous thrombosis?
Plasma antithrombin decreases during the initial 3 days of intravenous heparin therapy for DVT, and further monitoring may not be necessary if levels remain above 0.70 U/ml.
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Antithrombin decline during heparin for DVT was modest and weakly correlated; leaves open whether monitoring thresholds improve outcomes.
Holm et al. (1985) studied this question.
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