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October 1, 1995Blood Coagulation & Fibrinolysis

Markers of coagulation activation for evaluation of the antithrombotic efficacy of heparin

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Why the study?

Do markers of coagulation activation or anti-factor-Xa activity correlate with the antithrombotic efficacy of heparin in patients with acute DVT?

Population

50 patients with acute deep venous thrombosis (DVT)

Design

Cohort

Follow-up

7 days

Authors

RMRolf M. MestersUniversity Hospital MünsterTMThorsten MikoteitUniversity of BaselMSM. SchillerUniversity of Louisville

Discussion

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Implication

Anti-factor-Xa monitoring may better reflect heparin efficacy in acute DVT than APTT; hypothesis-generating and leaves open prospective validation before practice change.

Structured PICO

Do markers of coagulation activation or anti-factor-Xa activity correlate with the antithrombotic efficacy of heparin in patients with acute DVT?

P
Population
50 patients with acute deep venous thrombosis (DVT)
I
Intervention
Heparin therapy for 7 days, with doses adjusted according to activated partial thromboplastin time (APTT)
O
Outcome
Extent of thrombosis (reduced/unchanged vs extension) determined by compression ultrasonography on day 7surrogate

Plasma anti-factor-Xa activity correlates better with the antithrombotic efficacy of heparin in acute DVT than APTT or markers of coagulation activation.

Cite This Study

Mesters et al. (1995) studied this question.

synapsesocial.com/papers/6a9796cdda663e44ef76ef35https://doi.org/10.1097/00001721-199510000-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Markers of Hemostatic System Activation in Acute Deep Venous Thrombosis-Evolution during the First Days of Heparin Treatment1993 · 51 citations
  2. 2Prothrombin fragment 1 + 2, thrombin–antithrombin III complexes and D‐dimers in acute deep vein thrombosis: effects of heparin treatment1991 · 76 citations
  3. 3Persistent Thrombin Generation During Heparin Therapy in Patients With Acute Coronary Syndromes1997 · 47 citations
  4. 4Activated Partial Thromboplastin Time and Anti-Xa Measurements in Heparin Monitoring2013 · 95 citations
  5. 5D-Dimer and TAT Measurement in Patients with Deep Venous Thrombosis: Utility in Diagnosis and Judgement of Anticoagulant Treatment Effectiveness1990 · 82 citations