Key result
Hyperglycemia accelerates arterial thrombus formation in mice, driven by increased thrombin generation.
Why the study?
Does hyperglycemia accelerate arterial thrombus formation in a mouse model?
Population
Mice
Comparison
Hyperglycemia vs Nondiabetic mice (normoglycemia)
Design
Preclinical
Follow-up
24 hours (for endotoxin effect)
Authors
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Does not support changing clinical thrombosis prevention; leaves open translation of mouse findings to human hyperglycemia risk.
Does hyperglycemia accelerate arterial thrombus formation in a mouse model?
Hyperglycemia directly accelerates arterial thrombus formation and attenuates the antithrombotic response to systemic inflammation in a mouse model, providing a mechanistic link between high blood glucose and thrombosis risk.
Hansen et al. (2007) studied Arterial thrombosis. Hyperglycemia vs. Normoglycemia (nondiabetic mice) was evaluated on Time to occlusion and rate of thrombus formation. Hyperglycemia accelerated the rate of arterial thrombus formation in mice, an effect associated with increased thrombin generation and attenuation of the antithrombotic response to endotoxin.
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