Key result
Endothelial-to-mesenchymal transition drives occlusive vascular remodeling in PAH via altered BMPR2 signaling.
Endothelial-to-mesenchymal transition plays a role in the vascular remodeling of pulmonary arterial hypertension, suggesting a potential therapeutic target.
EndoMT-BMPR2 signaling merits therapeutic exploration in PAH; hypothesis-generating and requires prospective validation before any practice change.
EndoMT is linked to alterations in BPMR2 signaling and is involved in the occlusive vas cular remodeling of PAH, findings that may have therapeutic implications.
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Ranchoux et al. (2015) studied Pulmonary Arterial Hypertension. Pulmonary arterial hypertension vs. Control lung tissue (non-PAH) was evaluated on Evidence of endothelial-to-mesenchymal transition (EndoMT) in pulmonary vascular lesions. Endothelial-to-mesenchymal transition is linked to alterations in BMPR2 signaling and contributes to the occlusive vascular remodeling observed in human and experimental pulmonary arterial hypertension.
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