Population
Quail embryonic endothelial cells (in vivo in the dorsal aorta and in vitro)
Design
Preclinical
Follow-up
19 hours
Authors
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Challenges prevailing models of vascular smooth muscle origins; leaves open endothelial transdifferentiation relevance to human vascular disease.
This study provides the first direct in vivo evidence that embryonic endothelial cells can transdifferentiate into candidate vascular smooth muscle cells, offering new insights into vascular wall development.
DeRuiter et al. (1997) studied this question.
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