Key result
Myocardial basement membrane 30-nm particles initiate embryonic heart mesenchyme formation.
Population
Embryonic chick heart AV (atrioventricular canal) endothelium in collagen gel culture
Comparison
Resuspended pellet fraction of EDTA-extracted… vs Supernatant fraction and conditioned medium from…
Design
Preclinical
Authors
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Hypothesis-generating for cardiac EMT; extends avian models but leaves open mammalian translation.
The study demonstrates that 30-nm adheron-like particles in the myocardial basement membrane are necessary to induce epithelial-mesenchymal transition in embryonic chick heart endothelium.
Mjaatvedt et al. (1989) studied Embryonic heart development. Resuspended pellet fraction of MBM extracts (30-nm particles) vs. Supernatant fraction / Conditioned medium from L6 skeletal muscle cultures was evaluated on Initiation of mesenchyme formation from AV endothelium and N-CAM staining. The resuspended pellet fraction of myocardial basement membrane extracts containing 30-nm particles initiated differentiation of embryonic chick heart endothelium into mesenchyme.
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