February 15, 1996Circulation
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Population
Patients with advanced congestive heart failure
Design
Other
Authors
Discussion
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Member takes
Implication
May implicate TNF-alpha in HF progression; leaves open whether receptor modulation improves outcomes.
Structured PICO
P
Population
Patients with advanced congestive heart failure
O
Outcome
Expression levels of TNF receptor proteins and TNF-alphasurrogate
This study provides initial evidence that TNF-alpha and its receptors are upregulated in advanced heart failure, suggesting a maladaptive role in cardiac decompensation.
Cite This Study
Torre‐Amione et al. (1996) studied this question.