Population
HCN2 and CNGA1 channels
Comparison
Mutation to break salt bridges in the C-linker… vs Wild-type channels and mutant channels with…
Design
Preclinical
Authors
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Highlights salt bridges as closed-state stabilizers in HCN/CNGA1; extends modular gating models but leaves open human cardiac translation.
Salt bridges in the C-linker region of HCN2 and CNGA1 channels stabilize a closed conformation, and their disruption is required for channel opening, supporting a novel modular gating scheme.
Craven et al. (2004) studied this question.
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