Why the study?
Does pravastatin reduce platelet thrombus formation in hypercholesterolemia?
Does pravastatin reduce platelet thrombus formation in hypercholesterolemia?
Cholesterol lowering with pravastatin decreases platelet thrombus formation, suggesting a mechanism by which it reduces the risk of acute coronary events.
Pravastatin-associated reductions in platelet thrombus formation should not yet change practice; leaves open effects on clinical outcomes pending randomized trials.
Thus, hypercholesterolemia is associated with an enhanced platelet thrombus formation on an injured artery, increasing the propensity for acute thrombosis. Platelet thrombus formation at both high and low shear rates decreased as total and LDL cholesterol levels were reduced with pravastatin. Cholesterol lowering may therefore reduce the risk of acute coronary events in part by reducing the thrombogenic risk.
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Lacoste et al. (1995) studied this question.
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