Why the study?
Due to limited and conflicting data in pediatric patients, long-term routine surveillance endomyocardial biopsy after pediatric heart transplant remains controversial.
Does routine surveillance endomyocardial biopsy frequently detect significant rejection in pediatric heart transplant patients >2 years post-transplant?
Population
140 pediatric heart transplant patients with >2 year of post-HT biopsy data
Design
Single-institution retrospective cohort study
Follow-up
>2 year post-HT
Authors
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Low biopsy yield may support individualized surveillance >2 years post-pediatric HT; hypothesis-generating and requires prospective validation before practice change.
Does routine surveillance endomyocardial biopsy frequently detect significant rejection in pediatric heart transplant patients >2 years post-transplant?
Routine long-term surveillance biopsy yields a very low rate of detected rejection in pediatric heart transplant patients beyond 2 years, suggesting indiscriminate use should be reconsidered.
Peng et al. (2018) studied this question.
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