Why the study?
Does bicuspid aortic cusp fusion morphology alter aortic outflow patterns, wall shear stress, and expression of aortopathy?
Does bicuspid aortic cusp fusion morphology alter aortic outflow patterns, wall shear stress, and expression of aortopathy?
Bicuspid aortic valve fusion morphology alters aortic hemodynamics, suggesting a physiological mechanism linking valve phenotype to the expression of aortopathy.
Answers are grounded in this paper and cite their sources.
BAV fusion type may link valve phenotype to aortopathy via hemodynamics; leaves open whether it refines risk stratification or surveillance.
The presence and type of BAV fusion was associated with changes in regional wall shear stress distribution, systolic flow eccentricity, and expression of BAV aortopathy. Hemodynamic markers suggest a physiological mechanism by which the valve morphology phenotype can influence phenotypes of BAV aortopathy.
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Mahadevia et al. (2013) studied this question.
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