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In recent years, the trifluoromethoxy (OCF 3 ) functional group has received extensive attention in pharmaceuticals, agrochemicals and material sciences. However, the methods for the enantioselective synthesis of trifluoromethoxylated stereogenic carbon centers are rare owing to the nature of easy decomposition of OCF 3 anion and limited OCF 3 reagent. And the asymmetric trifluoromethoxylation will be a hot research topic in near future due to the unique biological properties of a single isomer. This article mainly focuses on the recent advances in the enantioselective construction of trifluoromethoxylated stereogenic carbon centers.
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Jiang et al. (2019) studied this question.
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