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Describe recent computational developments implemented within the online I-TASSER server to improve automated structural modeling accuracy and functional annotation.

April 16, 2015Nucleic Acids ResearchOpen Access

I-TASSER server: new development for protein structure and function predictions

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Authors

JYJianyi YangShandong University YZYang ZhangJohn Innes Centre

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Implication

Computational platform report demonstrates updated modeling pipelines for protein structure and function prediction, highlighting enhanced atomic refinement and accuracy estimation.

Key Points

Describe recent computational developments implemented within the online I-TASSER server to improve automated structural modeling accuracy and functional annotation.
Utilizes multiple threading alignment approaches to identify template structures from the Protein Data Bank.
Constructs full-length models through iterative fragment assembly simulations followed by database matching for functional annotation.
Incorporates new modules focused on atomic-level structure refinement, local prediction quality estimation, and biological function assignment.
Provides improved high-resolution atomic refinement and local error estimation for predicted protein models.
Enables more accurate structure-based functional annotations through updated pipeline algorithms and user-driven enhancements.

Cite This Study

Yang et al. (2015) studied this question.

synapsesocial.com/papers/69d9e88934ded318bb68459a https://doi.org/10.1093/nar/gkv342

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Implication

Computational platform report demonstrates updated modeling pipelines for protein structure and function prediction, highlighting enhanced atomic refinement and accuracy estimation.

I-TASSER server: new development for protein structure and function predictions

Discussion

Member takes

Implication

Key Points

Cite This Study

I-TASSER server: new development for protein structure and function predictions

Discussion

Member takes

Implication

Key Points

Cite This Study

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