Why the study?
Does nebivolol reduce nitroxidative stress and restore nitric oxide bioavailability in endothelial cells of Black Americans?
Does nebivolol reduce nitroxidative stress and restore nitric oxide bioavailability in endothelial cells of Black Americans?
Nebivolol restores endothelial nitric oxide bioavailability and reduces nitroxidative stress in Black Americans through mechanisms independent of beta1-blockade.
Hypothesis-generating for nebivolol in endothelial dysfunction among Black Americans; leaves open clinical translation and outcome benefits.
Reduced endothelial NO bioavailability in American blacks is mainly due to excessive O2- and ONOO- generation by NAD(P)H and uncoupled endothelial NO synthase. Nebivolol decreased O2- and ONOO- concentrations and restored NO bioavailability in blacks to the level recorded in cells from whites, independently of beta1-selective blockade.
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Mason et al. (2005) studied this question.
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