Why the study?
Does the SYNERGY biodegradable polymer everolimus eluting coronary stent maintain vascular compatibility compared to bare metal stent controls in a swine model?
Does the SYNERGY biodegradable polymer everolimus eluting coronary stent maintain vascular compatibility compared to bare metal stent controls in a swine model?
The SYNERGY biodegradable polymer everolimus-eluting stent demonstrated favorable vascular compatibility and safety in a preclinical swine model.
Supports preclinical vascular safety of SYNERGY stent; leaves open confirmation in human coronary trials.
In a swine model, everolimus was released by 90 days and PLGA bioabsorption was complete shortly thereafter. The SYNERGY stent and its biodegradable polymer, even at a 3× safety margin, demonstrated vascular compatibility similar to bare metal stent controls.
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Wilson et al. (2015) studied this question.
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