Why the study?
Does cardiomyocyte-specific expression of PPARgamma1 lead to cardiac dysfunction in mice?
Does cardiomyocyte-specific expression of PPARgamma1 lead to cardiac dysfunction in mice?
Direct actions of PPARgamma on the myocardium lead to dilated cardiomyopathy in mice, providing a potential mechanism for the increased heart failure risk seen with PPARgamma agonists in humans.
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May explain HF risk with PPARγ agonists via direct myocardial effects; leaves open translation from transgenic mice to clinical use.
Son et al. (2007) studied this question.
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