What question did this study set out to answer?

This research investigates the role of G protein alterations in the contractile dysfunction observed in heart failure.

July 1, 1988Journal of Clinical InvestigationOpen Access

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

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Population

Failing human myocardium and nonfailing controls

Design

Preclinical

Authors

AFArthur M. FeldmanThe Wistar Institute ACAndreé E. CatesJohns Hopkins University WVW B VeazeyJohns Hopkins University

Discussion

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Implication

Alpha G40 merits study as a contributor to beta-adrenergic hyporesponsiveness in heart failure; leaves open its value as a therapeutic target.

Key Points

This research investigates the role of G protein alterations in the contractile dysfunction observed in heart failure.
Measured G protein activity in failing human myocardium using bacterial toxin-catalyzed ADP ribosylation
Compared the activity of alpha G40 between failing and nonfailing human hearts
Assessed adenylate cyclase activity in response to stimulation
Activity of alpha G40 increased by 36% in failing hearts compared to controls
Basal and stimulated adenylate cyclase activity decreased by 30%
Increased alpha G40 activity indicates a potential new marker for failing myocardium

Structured PICO

Population

Failing human myocardium and nonfailing controls

Comparator

Nonfailing controls

Outcome

Activity of a 40,000-mol wt pertussis toxin substrate (alpha G40)surrogate

Increased alpha G40 activity is a marker for failing myocardium and may explain the diminished responsiveness to beta-adrenergic agonists in heart failure.

Cite This Study

Feldman et al. (1988) studied this question.

synapsesocial.com/papers/69da3ec184371aa676a3d07a https://doi.org/10.1172/jci113569

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Implication

Alpha G40 merits study as a contributor to beta-adrenergic hyporesponsiveness in heart failure; leaves open its value as a therapeutic target.

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider