Is an eGFRcys at least 30% lower than eGFRcr associated with higher rates of all-cause mortality, cardiovascular events, and kidney failure?
Discordance between cystatin C-based and creatinine-based eGFR (eGFRcys ≥30% lower than eGFRcr) identifies patients at significantly higher risk for mortality, cardiovascular events, and kidney failure.
In the CKD-PC, 11% of outpatient participants and 35% of hospitalized patients had an eGFRcys that was at least 30% lower than their eGFRcr. In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.
Estrella et al. (Fri,) studied this question.