What question did this study set out to answer?

To describe the occurrence of severe rhabdomyolysis and acute renal failure in cardiac transplant recipients treated concurrently with lovastatin and cyclosporine.

July 8, 1988JAMA

Rhabdomyolysis and Renal Injury With Lovastatin Use

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To describe the occurrence of severe rhabdomyolysis and acute renal failure in cardiac transplant recipients treated concurrently with lovastatin and cyclosporine.
Clinical case evaluation of two cardiac transplant recipients who received lovastatin for hypercholesterolemia in combination with cyclosporine-containing immunosuppressive regimens.
Monitoring of clinical progression, serum creatine kinase, hepatic transaminases, and renal recovery following cessation of therapy.
Both cardiac transplant recipients developed severe rhabdomyolysis and acute renal failure following concurrent administration of lovastatin and cyclosporine.
Discontinuation of both lovastatin and cyclosporine led to the resolution of muscle damage and clinical improvement.

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Implication

Case series reveals acute renal failure and rhabdomyolysis in cardiac transplant recipients receiving lovastatin with cyclosporine, highlighting the need for close biochemical monitoring.

Cite This Study

Cindy L. Corpier (1988) studied this question.

synapsesocial.com/papers/69dab6deaae38ff6ad836156 https://doi.org/10.1001/jama.1988.03410020105038

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Implication

Case series reveals acute renal failure and rhabdomyolysis in cardiac transplant recipients receiving lovastatin with cyclosporine, highlighting the need for close biochemical monitoring.

Rhabdomyolysis and Renal Injury With Lovastatin Use

Key Points

Discussion

Implication

Cite This Study

Rhabdomyolysis and Renal Injury With Lovastatin Use

Key Points

Discussion

Implication

Cite This Study

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