Does losartan limit aortic dilatation in patients >10 years old with Marfan Syndrome?
Losartan does not limit aortic dilatation in Marfan syndrome patients over 10 years old, supporting beta-blockers as standard first-line therapy.
Losartan was able to decrease blood pressure in patients with MFS but not to limit aortic dilatation during a 3-year period in patients >10 years old. β-Blocker therapy alone should therefore remain the standard first line therapy in these patients.
Milleron et al. (Sat,) studied this question.