Does pioglitazone improve LV remodeling and function in mice with post-MI heart failure?
Pioglitazone shows promise in attenuating LV remodeling and improving function in a preclinical model of post-MI heart failure.
Pioglitazone improved LV remodeling and function in mice with post-MI heart failure. This effect was associated with an attenuated LV expression of inflammatory cytokines and chemokines. Peroxisome proliferator-activated receptor-gamma ligands have promise as preventive and therapeutic agents against heart failure.
Shiomi et al. (Tue,) studied this question.