Why the study?
Are catheter-measured hemodynamics associated with adverse events and end-organ dysfunctions in symptomatic adult Fontan patients?
Are catheter-measured hemodynamics associated with adverse events and end-organ dysfunctions in symptomatic adult Fontan patients?
In adult Fontan patients, higher CVP and PCWP are associated with hepatic dysfunction and portal venous outflow obstruction, though hemodynamic parameters did not independently predict adverse events in multivariate analysis.
Catheter hemodynamics did not independently predict events; leaves open their role in hepatic risk assessment for adult Fontan patients.
Symptomatic adult Fontan patients who experienced an event manifested with a higher CI and CVP, although the multivariate Cox proportional hazard analysis did not yield any significant associations. The presences of hepatic dysfunction and portal venous outflow obstruction were associated with a higher CVP and PCWP. Renal dysfunction was prevalent but no statistically significant association between the hemodynamic measurements was identified, although trends toward a higher CVP and transpulmonary gradient were identified.
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Mori et al. (2016) studied this question.