June 1, 2004DiabetesOpen Access

Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

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Why the study?

Does insulin infusion increase microvascular recruitment and glucose uptake in rat skeletal muscle in vivo?

Population

Rat skeletal muscle in vivo

Comparison

30-min physiological infusion of insulin (3 mU… vs Saline infusion

Design

Preclinical

Follow-up

30 minutes

Authors

MVMichelle A. VincentUniversity of Virginia LCLucy H. ClerkUniversity of Virginia JLJonathan R. LindnerUniversity of Virginia Health System

Discussion

Member takes

Implication

Insulin recruits rat muscle microvasculature early via NO; leaves open translation to human glucose metabolism.

Structured PICO

Does insulin infusion increase microvascular recruitment and glucose uptake in rat skeletal muscle in vivo?

Population

Rat skeletal muscle in vivo

Intervention

30-min physiological infusion of insulin (3 mU. min(-1). kg(-1), euglycemic clamp) with or without l-NAME (N(omega)-nitro-l-arginine-methyl ester)

Comparator

Saline infusion

Outcome

Temporal sequence of vascular and metabolic responses (microvascular volume, glucose disposal, and total leg blood flow)surrogate

Insulin rapidly recruits skeletal muscle capillaries in vivo via a nitric oxide-dependent mechanism, which precedes and contributes to subsequent glucose uptake.

Cite This Study

Vincent et al. (2004) studied this question.

synapsesocial.com/papers/69db23cf1e19c8ae08836ab3 https://doi.org/10.2337/diabetes.53.6.1418

View Full Paper

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Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider