Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials

Key Points

• The aim is to explain how different analytical approaches affect the understanding of treatment effects in clinical trials.
• Descriptive overview of intention-to-treat, per-protocol, and as-treated analysis methods.
• Discussion on patient population variations across different analytical approaches.
• Examination of implications for treatment effect interpretation.
• Clarification of how treatment assignment impacts interpretation of clinical trial results.
• Insight into choosing the appropriate analysis method for accurate outcome assessment.