August 1, 2001Hypertension
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
Why the study?
How do aging and essential hypertension affect NO availability and oxidative stress as measured by endothelium-dependent vasodilation?
Population
96 subjects, comprising 47 normotensive subjects and 49 patients with essential hypertension.
Comparison
Intrabrachial sodium nitroprusside and… vs Normotensive subjects versus hypertensive…
Design
Cross-sectional
Authors
Discussion
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Implication
Endothelial dysfunction linked to hypertension and aging should not yet alter practice; leaves open longitudinal confirmation of sequential NO and oxidative mechanisms.
Structured PICO
How do aging and essential hypertension affect NO availability and oxidative stress as measured by endothelium-dependent vasodilation?
P
Population
96 subjects, comprising 47 normotensive subjects and 49 patients with essential hypertension.
I
Intervention
Intrabrachial sodium nitroprusside (1, 2, and 4 microg/100 mL per minute) and acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 microg/100 mL per minute), with acetylcholine repeated in the presence of NO synthase inhibitor L-NMMA (100 microg/100 mL per minute), antioxidant vitamin C (8 mg/100 mL per minute), or both.
C
Comparator
Normotensive subjects versus hypertensive patients, as well as comparisons across different age groups.
O
Outcome
Forearm blood flow modifications (vasodilation) evaluated by strain-gauge plethysmography.surrogate
Aging and hypertension are associated with reduced endothelium-dependent vasodilation, driven by an early primary dysfunction of the NO system and a later production of oxidative stress.
Cite This Study
Taddei et al. (2001) studied this question.