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April 13, 2026Reproduction and FertilityOpen Access

Interconnection between Polycystic Ovary Syndrome, Immune Disorders, and Reproductive Outcomes

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Authors

TRThaís Bastos RomeroDSDaniel de Sousa SobralLALara Andryne Alves Aguiar

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Overview

This review demonstrates how immune system issues affect fertility in women with PCOS, suggesting targeted therapies.

Key Points

  • The aim is to explore the links between PCOS, immune system dysfunction, and reproductive outcomes.
  • Review of recent studies on PCOS and immune dysregulation
  • Analysis of effects of chronic inflammation on fertility
  • Review of existing treatments like metformin and GLP-1 receptor agonists
  • PCOS is associated with chronic low-grade inflammation affecting ovarian function.
  • Women with PCOS show higher rates of autoimmune diseases impacting pregnancy.
  • Certain treatments can improve immune balance and support fertility.

Cite This Study

Romero et al. (2026) studied this question.

synapsesocial.com/papers/69dc87983afacbeac03e9dcchttps://doi.org/10.1530/raf-25-0186
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunological aspects of polycystic ovary syndrome: A review2025
  2. 2Polycystic Ovary Syndrome, Obesity and Reproductive Implications2009 · 84 citations
  3. 3Reproductive Dysfunction in Women with PCOS: A Review Article2024 · 1 citations
  4. 4Exploring Emerging Concepts in the Pathophysiology of PCOS: Microbiome Dysbiosis and Immunological Dysregulation2026
  5. 5The role of immunity in insulin resistance in patients with polycystic ovary syndrome2025 · 11 citations