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March 31, 2004New England Journal of MedicineOpen Access

C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease

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Why the study?

Does C-reactive protein predict coronary heart disease?

Design

Other

Authors

JDJohn DaneshSemmelweis UniversityJWJeremy G. WheelerUniversity of LondonGHGideon M. HirschfieldNational Health Service

Discussion

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Implication

May temper CRP use in CHD risk assessment; leaves open its incremental value in prospective models.

Structured PICO

Does C-reactive protein predict coronary heart disease?

I
Intervention
C-reactive protein and other circulating markers of inflammation
O
Outcome
Coronary heart disease

C-reactive protein is a relatively moderate predictor of coronary heart disease, suggesting current recommendations for its use may need reevaluation.

Cite This Study

Danesh et al. (2004) studied this question.

synapsesocial.com/papers/69dc8a89d4d0de07d1133586https://doi.org/10.1056/nejmoa032804
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events2002 · 3,623 citations
  2. 2Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study1996 · 1,103 citations
  3. 3Prothrombin fragment 1+2 is a risk factor for myocardial infarction in treated hypertensive men1998 · 55 citations
  4. 4Underestimation of Risk Associations Due to Regression Dilution in Long-term Follow-up of Prospective Studies1999 · 892 citations
  5. 5C-reactive protein: relation to total mortality, cardiovascular mortality and cardiovascular risk factors in men2000 · 363 citations