September 29, 2013Nephrology Dialysis Transplantation109 citationsOpen Access
View Full PaperPreoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery
Structured PICO
Does preoperative ACEi/ARB usage increase the risk of acute kidney injury in patients undergoing cardiac surgery?
P
Population
Patients undergoing cardiac surgery
I
Intervention
Preoperative angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blocker (ARB) use
O
Outcome
Acute kidney injury (functional and structural)safety
Preoperative ACEi/ARB use in cardiac surgery is associated with functional acute kidney injury, highlighting the need for randomized trials to determine optimal perioperative management.
Abstract
Preoperative ACEi/ARB usage was associated with functional but not structural acute kidney injury. As AKI from ACEi/ARB in this setting is unclear, interventional studies testing different strategies of perioperative ACEi/ARB use are warranted.