Population
Mice (wild-type, heterozygotes, and Npr3 -/- homozygotes)
Comparison
Inactivation of the Npr3 gene by homologous… vs Wild-type mice
Design
Preclinical
Authors
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NPRC knockout in mice suggests BP-lowering potential via prolonged natriuretic peptides; leaves open human translation given skeletal effects.
Inactivation of the NPRC gene in mice prolongs the half-life of natriuretic peptides, lowers blood pressure, and causes skeletal deformities, demonstrating its physiological role as a clearance receptor that modulates local natriuretic peptide effects.
Matsukawa et al. (1999) studied this question.
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