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June 1, 1969Annual Review of Biochemistry

Circulating Lipoproteins

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Authors

VSVerne N. SchumakerGAGeorge H. Adams

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Overview

Scientific overview reveals essential functions of the Hippo signaling pathway in regulating organ size, highlighting evolutionary mechanisms that govern cell fate.

Key Points

  • To review the evolutionary conservation and fundamental biological functions of the Hippo signaling pathway in tissue growth and organ development.
  • Literature review of cellular and molecular studies originating in Drosophila melanogaster model systems.
  • Evaluation of downstream signaling mechanisms that influence cell proliferation, survival, and fate decisions.
  • The Hippo signaling cascade is highly conserved across evolution and acts as a central governor of cellular growth and organ size control.
  • Pathway components modulate vital developmental outcomes by strictly balancing cell fate choices and physiological tissue expansion.

Cite This Study

Schumaker et al. (1969) studied this question.

synapsesocial.com/papers/69dd49fd5ea84e5556100ed7https://doi.org/10.1146/annurev.bi.38.070169.000553
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