Why the study?
Do different rotavirus vaccines exert different immunological pressures influencing the diversity of circulating rotavirus strains in Australia?
Do different rotavirus vaccines exert different immunological pressures influencing the diversity of circulating rotavirus strains in Australia?
Different rotavirus vaccines appear to exert distinct immunological pressures that influence the diversity of circulating rotavirus strains.
May indicate vaccine-specific strain selection; leaves open effects on disease burden or policy.
The increased diversity and differences in genotype dominance observed in states using RotaTeq (G12P[8]), and in states and territories using Rotarix (equine-like G3P[8] and G2P[4]), suggest that these vaccines exert different immunological pressures that influence the diversity of rotavirus strains circulating in Australia.
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Roczo‐Farkas et al. (2018) studied this question.
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