Synthesis of some novel fluorinated 4-thiazolidinones containing amide linkages and their antimicrobial screening

Efficient syntheses of some 4-thiazolidinones are described. A series of 2-(substituted phenyl)-3-[4-(2,4-dichloro-5-fluorophenyl)-6-(2-thienyl)pyrimidine-2-yl-ureido]-5H/methyl/carboxymethyl-4-thiazolidinones 5a-e,6a-e,7a-e were prepared. The structures of the synthesised compounds were assigned on the basis of elemental analysis, IR and 1 H NMR spectral data. All the products were screened against different strains of bacteria and fungi.