What question did this study set out to answer?

To determine whether an increase in serotype O foot-and-mouth disease outbreaks across Kenya was driven by a single widespread strain or multiple independent lineages.

August 12, 2013Transboundary and Emerging DiseasesOpen Access

Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from Livestock in Kenya: Evidence of Four Independently Evolving Lineages

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Population

Foot-and-mouth disease (FMD) serotype O viruses sampled from livestock in Kenya during 2010 and 2011

Comparison

Sequence analysis of the complete VP1-coding… vs Earlier type O isolates from Eastern Africa

Design

Other

Authors

SWSabenzia Nabalayo WekesaMinistry of Agriculture Livestock and Fisheries VMVincent B. MuwanikaMakerere University HSHans R. SiegismundUniversity of Copenhagen

Discussion

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Implication

Multiple independent FMD lineages drove 2010-2011 Kenyan outbreaks; leaves open need for enhanced genomic surveillance in endemic regions.

Key Points

To determine whether an increase in serotype O foot-and-mouth disease outbreaks across Kenya was driven by a single widespread strain or multiple independent lineages.
Sequenced the complete VP1-coding region of serotype O foot-and-mouth disease virus isolates collected from different regions of Kenya during 2010 and 2011.
Performed phylogenetic comparisons of the isolated sequences against earlier type O reference isolates from Eastern Africa.
Identified four distinct, independently evolving viral strains responsible for the 2010–2011 outbreaks.
Determined that outbreaks were driven by three lineages within topotype EA-2 and one strain within topotype EA-4, whereas topotypes EA-1 and EA-3 were absent.

Structured PICO

Population

Foot-and-mouth disease (FMD) serotype O viruses sampled from livestock in Kenya during 2010 and 2011

Intervention

Sequence analysis of the complete VP1-coding region

Comparator

Earlier type O isolates from Eastern Africa

Outcome

Characteristics and lineage of the FMD serotype O viruses causing the outbreaks

The 2010-2011 FMD serotype O outbreaks in Kenya were caused by four independently evolving lineages rather than a single spreading strain.

Cite This Study

Wekesa et al. (2013) studied this question.

synapsesocial.com/papers/69dd595980eea7d3f699ba9d https://doi.org/10.1111/tbed.12152

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Implication

Multiple independent FMD lineages drove 2010-2011 Kenyan outbreaks; leaves open need for enhanced genomic surveillance in endemic regions.

Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from Livestock in Kenya: Evidence of Four Independently Evolving Lineages

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Analysis of Recent Serotype O Foot-and-Mouth Disease Viruses from Livestock in Kenya: Evidence of Four Independently Evolving Lineages

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider