Why the study?
Does local wound infiltration with ketamine versus dexmedetomidine improve postoperative pain and stress in patients undergoing total abdominal hysterectomy?
Does local wound infiltration with ketamine versus dexmedetomidine improve postoperative pain and stress in patients undergoing total abdominal hysterectomy?
Local wound infiltration with ketamine added to bupivacaine may offer superior attenuation of postoperative stress compared to dexmedetomidine after abdominal hysterectomy.
This is the authors' abstract. We don't add key points for this paper.
Local wound infiltration with ketamine or dexmedetomidine added to bupivacaine had an opioid-sparing effect, delayed first request of rescue analgesia, and attenuated postoperative stress response, especially with ketamine in patients underwent total abdominal hysterectomy.
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Favors ketamine over dexmedetomidine as bupivacaine adjunct after hysterectomy; extends RCT evidence for opioid-sparing local infiltration.
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Mohamed et al. (2018) studied this question.
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