What question did this study set out to answer?

This research examines the structures and functions of ACAT1 and ACAT2, focusing on their roles in cholesterol metabolism and atherosclerosis.

Acyl coenzyme A : cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis

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Randomized trial investigates cholesterol ester formation in atherosclerosis models, indicating distinct metabolic roles for ACAT1 and ACAT2.

This research examines the structures and functions of ACAT1 and ACAT2, focusing on their roles in cholesterol metabolism and atherosclerosis.
Disruption experiments of ACAT1 and ACAT2 genes in mice to assess cholesterol homeostasis and esterification.
Assays of liver and intestinal microsomes from ACAT2 −/− mice to evaluate cholesterol ester formation.
Studies in non-human primates to investigate ACAT localization in various tissues.
ACAT1 −/− mice show reduced atherosclerosis compared to ACAT1 +/+ mice, indicating ACAT1's role in cholesterol regulation in macrophages.
ACAT2 −/− mice exhibit limited cholesterol absorption and significantly lower cholesterol ester levels in liver and plasma.
Distinct localization and membrane topology between ACAT1 and ACAT2 suggest their complementary functions in cholesterol metabolism.

Rudel et al. (2001) studied this question.

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Randomized trial investigates cholesterol ester formation in atherosclerosis models, indicating distinct metabolic roles for ACAT1 and ACAT2.