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January 1, 2021Cell ReportsOpen Access

Cancer Stemness Meets Immunity: From Mechanism to Therapy

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Authors

PCPeiwen ChenNanjing Xiaozhuang UniversityWHWen‐Hao HsuAU Optronics (Taiwan)JHJincheng HanBeijing Institute of Technology

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Implication

Mechanistic review uncovers symbiotic crosstalk between cancer stem cells and immune cells in tumors, highlighting strategies to disrupt mutual microenvironmental niches.

Key Points

  • To delineate the cellular and molecular mechanisms governing mutual interactions between cancer stem cells and the immune microenvironment, and to identify therapeutic strategies that interrupt this co-dependency.
  • Reviewed pan-cancer transcriptomic analyses linking cancer stemness properties with specific immune gene signatures.
  • Synthesized molecular and cellular evidence detailing heterotypic cross-talk between cancer stem cells and infiltrating immune populations.
  • Cancer stem cells actively modulate the tumor microenvironment by recruiting and polarizing tumor-associated macrophages, myeloid-derived suppressor cells, and T cells.
  • Reciprocally, tumor-infiltrating immune cells maintain cancer stem cell survival niches, accelerating tumor initiation, metastatic dissemination, and therapeutic resistance.

Cite This Study

Chen et al. (2021) studied this question.

synapsesocial.com/papers/69ddf5f4da08968cf7b0bdebhttps://doi.org/10.1016/j.celrep.2020.108597
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