Adherence and related cardiovascular outcomes to single pill vs. separate pill administration of antihypertensive triple-combination therapy

Figures

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  FIGURE 1. Risk ratios (RR), and 95% confidence intervals (CI), estimating the association between high adherence to treatment (PDC > 75%) and single-pill combination vs. the two-pill combination. Three categories were considered for the clinical profile according to the Multisource Comorbidity Score (MCS): good (0 ≤ MCS ≤ 4), intermediate (5 ≤ MCS ≤ 14), and poor (MCS ≥ 15).

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  FIGURE 2. Risk ratios (RR), and 95% confidence intervals (CI), estimating the association between low adherence to treatment (PDC < 25%) and single-pill combination vs. the two-pill combination. Three categories were considered for the clinical profile according to the Multisource Comorbidity Score (MCS): good (0 ≤ MCS ≤ 4), intermediate (5 ≤ MCS ≤ 14), and poor (MCS ≥ 15).

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  FIGURE 3. Risk ratios (RR), and 95% confidence intervals (CI), estimating the association between treatment discontinuation and single-pill combination vs. the two-pill combination. Three categories were considered for the clinical profile according to the Multisource Comorbidity Score (MCS): good (0 ≤ MCS≤4), intermediate (5 ≤ MCS ≤ 14), and poor (MCS ≥ 15).

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  FIGURE 4. Hazard ratios (HR), and 95% confidence intervals (CI), for cardiovascular hospitalization associated with adherence to antihypertensive drugs, after adjustment for the baseline characteristics. Meta-analytic procedures were used for summarized estimates. Adherence categories are: very low (PDC < 25%), low (25% ≤ PDC < 50%), intermediate (50 ≤ PDC ≤ 75%), and high (PDC >75).