Why the study?
Approximately 25% of hypertensive patients require triple-combination therapy, and nonadherence increases morbidity and mortality, prompting a comparison of adherence across different triple-combination regimens.
Does single-pill triple-combination therapy improve medication adherence compared to free triple-combination therapy or fixed-dose dual-combination plus a third agent in hypertensive patients?
Does single-pill triple-combination therapy improve medication adherence compared to free triple-combination therapy or fixed-dose dual-combination plus a third agent in hypertensive patients?
Different definitions of adherence can significantly alter measured adherence rates among patients on complex antihypertensive regimens, with relaxed definitions showing better adherence for multi-pill regimens compared to single-pill combinations.
Single-pill triple-combination therapy showed no adherence benefit versus free combinations in this retrospective analysis; leaves open whether pill burden reduction improves persistence in hypertension.
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Wang et al. (2019) studied this question.
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