What question did this study set out to answer?

To systematically review and quantify the degree of correlation between neurofilament light chain protein levels measured in cerebrospinal fluid and those measured in peripheral blood.

June 1, 2021SHILAP Revista de lepidopterologíaOpen Access

Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis

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Authors

JAJasmini AlagaratnamChelsea and Westminster Hospital NHS Foundation Trust SWSophia von WidekindImperial College London DFDavide De FrancescoStanford Medicine

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Implication

Systematic review and meta-analysis reveals the correlation between CSF and blood neurofilament light chain levels, highlighting blood tests as potential surrogates for invasive spinal taps.

Key Points

To systematically review and quantify the degree of correlation between neurofilament light chain protein levels measured in cerebrospinal fluid and those measured in peripheral blood.
Conducted a systematic review and meta-analysis under prospective protocol registration CRD42019140469.
Identified and synthesized clinical studies evaluating paired cerebrospinal fluid (CSF) and blood (serum or plasma) neurofilament light chain (NfL) measurements.
Synthesized quantitative correlation coefficients between blood-based and CSF-derived neurofilament light chain concentrations across published cohorts.
Evaluated the strength and consistency of the association to determine the viability of blood NfL as a minimally invasive surrogate for central nervous system NfL levels.

Cite This Study

Alagaratnam et al. (2021) studied this question.

synapsesocial.com/papers/69de6b6b726bee048db0c047 https://doi.org/10.1136/bmjno-2021-000143

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Implication

Systematic review and meta-analysis reveals the correlation between CSF and blood neurofilament light chain levels, highlighting blood tests as potential surrogates for invasive spinal taps.

Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation between CSF and blood neurofilament light chain protein: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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