Longitudinal Association of Non‐Alcoholic Fatty Liver Disease With Changes in Myocardial Structure and Function: The CARDIA Study
Why the study?
NAFLD is associated with high cardiovascular morbidity and mortality including heart failure, and abnormalities in LV structure and function are linked to heart failure risk.
Is non-alcoholic fatty liver disease associated with adverse changes in myocardial structure and function over time in middle-aged adults?
Population
1827 CARDIA study participants aged 43-55 years with CT-measured liver fat and echocardiography
Comparison
NAFLD vs non-NAFLD
Design
Population-based cohort study
Authors
Discussion
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Member takes
Implication
NAFLD-LV remodeling links attenuate after BMI adjustment; leaves open whether NAFLD independently affects cardiac structure.
Structured PICO
Is non-alcoholic fatty liver disease associated with adverse changes in myocardial structure and function over time in middle-aged adults?
P
Population
1,827 participants from the population-based CARDIA study year 25 exam (aged 43-55 years, 61% women, 48% black) with computed tomography measured liver fat and comprehensive echocardiography.
I
Intervention
Non-alcoholic fatty liver disease (NAFLD) defined as liver attenuation ≤40 HU
C
Comparator
Participants without NAFLD
O
Outcome
Changes in left ventricular (LV) structure and function (incident LV hypertrophy, abnormal LV geometry, change in strain)surrogate
NAFLD is associated with subclinical changes in LV structure and function over time, but this association is largely explained by coexisting obesity.
Cite This Study
VanWagner et al. (2020) studied this question.