Combination therapy is essential for achieving blood pressure targets in most hypertensive patients, particularly those with significantly elevated blood pressure or high cardiovascular risk.
Reinforces guideline-endorsed dual antihypertensive therapy; leaves open optimal triple regimens for the subset requiring escalation.
Hypertension is a major preventable risk factor for atherosclerosis and ischemic heart disease. Although modern and effective antihypertensive drugs are available, most patients remain with a suboptimal blood pressure control. Most hypertensive patients will need a combination of antihypertensive agents to achieve the therapeutic goals - recent guidelines recommend initiating treatment with two drugs in those patients with a systolic blood pressure >20 mmHg and/or a diastolic blood pressure >10 mmHg above the goals, and in those patients with high cardiovascular risk. In addition, approximately 25% of patients will require three antihypertensive agents to achieve the therapeutic targets. In this review, we analyse the latest information available regarding the treatment of hypertension with combination therapy.
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Guerrero-García et al. (2018) studied this question.
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