Why the study?
Does initial low-dose combination antihypertensive therapy improve hypertension control in patients with essential hypertension compared to single drug therapy?
Does initial low-dose combination antihypertensive therapy improve hypertension control in patients with essential hypertension compared to single drug therapy?
Initial low-dose combination therapy may provide a more effective and practical approach to achieving blood pressure control in essential hypertension compared to monotherapy.
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Supports low-dose combination initiation in primary care hypertension; leaves open need for RCTs versus monotherapy.
Welsh et al. (2004) studied this question.
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