Why the study?
Does terodiline cause concentration-dependent cardiotoxicity (QTc and QTd prolongation) in patients treated for urinary incontinence?
Does terodiline cause concentration-dependent cardiotoxicity (QTc and QTd prolongation) in patients treated for urinary incontinence?
Terodiline causes concentration-dependent QTc and QTd prolongation, suggesting its risk for torsade de pointes is a dose-dependent adverse reaction.
May warrant QT monitoring with terodiline; leaves open the clinical torsades risk magnitude in incontinence.
Terodiline increases QTc and QTd in a concentration dependent manner. It is not clear whether this is a stereoselective effect and, if so, which enantiomer is responsible. The results suggest that drug induced torsade de pointes is a type A (concentration dependent) adverse drug reaction.
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Thomas et al. (1995) studied this question.
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