Why the study?
Does the R(+)- or S(-)-enantiomer of terodiline cause QT prolongation in healthy volunteers compared to placebo?
Does the R(+)- or S(-)-enantiomer of terodiline cause QT prolongation in healthy volunteers compared to placebo?
The QT prolongation and associated ventricular arrhythmias caused by racemic terodiline are exclusively attributable to its R(+)-enantiomer.
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R(+)- but not S(-)-terodiline prolongs QTc; confirms enantiomer-specific cardiotoxicity and supports avoiding the racemate.
Hartigan‐Go et al. (1996) studied this question.
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