Why the study?
Does terodiline inhibit delayed-rectifier K+ currents in guinea-pig ventricular myocytes?
Does terodiline inhibit delayed-rectifier K+ currents in guinea-pig ventricular myocytes?
Terodiline at therapeutic concentrations prolongs the QT interval primarily by inhibiting the rapid component of the delayed-rectifier K+ current (IKr).
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May underlie clinical QT prolongation; leaves open human proarrhythmia confirmation.
Jones et al. (1998) studied this question.
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