Key result
Ketanserin (50 μmol/L) significantly prolonged action potential duration at 50% and 90% repolarization by 218% and 256% (P < .05) by inhibiting the transient outward potassium current.
p-value: p=< .05
Ketanserin prolongs action potential duration in rat ventricular myocytes by inhibiting the transient outward potassium current (Ito) and sustained current (ISus), providing a potential mechanism for its QT-prolonging effects.
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Ketanserin’s Ito inhibition may underlie QT prolongation in rodents; leaves open translation to human proarrhythmia risk.
Zhang et al. (1994) studied this question. Ketanserin vs. Control condition was evaluated on Action potential duration (APD) and transient outward potassium current (Ito) (p=< .05). Ketanserin (50 μmol/L) significantly prolonged action potential duration at 50% and 90% repolarization by 218% and 256% (P < .05) by inhibiting the transient outward potassium current.
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