Key result
Ketanserin concentration-dependently reduces the calcium-independent transient outward potassium current in rabbit ventricular myocytes.
Why the study?
The effects of ketanserin on the calcium-independent component of the transient outward potassium current (Ito) in ventricular myocytes were not fully understood.
Does ketanserin inhibit the transient outward potassium current in isolated rabbit ventricular myocytes?
Population
Isolated rabbit ventricular myocytes
Comparison
Ketanserin concentration-dependent exposure (0.1-100 microM) vs baseline
Design
Whole-cell patch-clamp electrophysiological study
Authors
Loading...
May suggest proarrhythmic mechanism via Ito inhibition; leaves open relevance to human ventricular electrophysiology.
Does ketanserin inhibit the transient outward potassium current in isolated rabbit ventricular myocytes?
Effect estimate: IC50 2.25 +/- 2.2 microM
Ketanserin inhibits the transient outward potassium current in rabbit ventricular myocytes, providing a potential mechanism for its proarrhythmic effects.
Grand et al. (1995) studied this question. Ketanserin was evaluated on calcium-independent component of the transient outward potassium current (Ito) (IC50 2.25 +/- 2.2 microM). Ketanserin concentration-dependently reduced the calcium-independent component of the transient outward potassium current (Ito) in isolated rabbit ventricular myocytes (IC50 2.25 +/- 2.2 microM).